Archives

KSMs & Intermediates

KSMs & Intermediates

S. NO NAME OF INTERMEDIATE CAS NO . CATEGORY
1 3-(Diethylboraneyl)pyridine 89878-14-8 KSM of Abiraterone Acetate
2 (3S,8R,9S,10S,13S,14S,Z)-17-hydrazineylidene-10,13-dimethyl-2-3,4,5,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[ɑ]phenantheren-3-ol NA Intermediate of Abiraterone Acetate
3 (3S,8R,9S,10S,13S,14S)-17-iodo-10,13-dimethyl-2-3,4,5,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[ɑ]phenantheren-3-ol 32138-69-5 Intermediate of Abiraterone Acetate
4 (3S,8R,9SI0S,13S,14S)-10,13-dimethyl-17- (pyridin-3-yl)-2,3,4,5,8,9,10,1 1,12,13,14,15- dodecahydro- IH-  cyc1openta[a]phenanthren-3- ol NA Intermediate of Abiraterone Acetate
5 2,2′ (5  methyl- 1,3-phenylene)bis(2- methylpropanenitrile) 120511-72-0 KSM of Anastrozole
6 2,2′-(5-(bromomethyl)-1,3-pheny1ene) bis(2-methylpropanenitrile) 120511 -84-4 Intermediate of Anastrozole
7 4-Amino-2-fIuoro-N-methyIbenzamide 915087-25-1 KSM of Apalutamide
8 2-Fluoro-N-methyl-4-nitrobenzamide 915087-24-0 KSM of Apalutamide
9 5-Amino-3-(trifluoromethyl)picolinonitriìe 573762-62-6 KSM of Apalutamide
10 5-Nitro-3-(trif1uoromethyl)picolinonitrile 573762-57-9 KSM of Apalutamide
11 2-Bromo-5-nitro-3-(trif1uoromethyl)pyridine 956104-42-0 KSM of Apalutamide
12 4-((1-cyanocycIobutyI)amino)-2-fìuoro-N-methyIbenzamide 915087-26-2 Intermediate for Apalutamide
13 (3R,4R,5R)-5-(acetoxymethyl)   tetrahydrofuran-2,3,4-triyl triacetate 28708-32-9 KSM of Azacitidine
14 5-Azacytosine             931-86-2  KSM of Azacitidine
15 Guanyl urea formate NA RM of  Azacitidine
16 (2R,3R,4R,5R)-2-(acetoxymethyl)-5-(4-amino-2-oxo-1,3,5-triazin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate 10302-78-0 Intermediate of Azacitidine
17 Ethyl 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate 3543-73-5 KSM of Bendamustine
18 Ethyl 4-(5-(bis(2-hydroxyethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate 3543-74-6 lntermediate  of Bendamustine
19 Ethyl 4-(5-(bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate 87475-54-5 lntermediate  of Bendamustine
20 N-(4-Cyano-3-(trifluromethyl)phenyl)methacrylamide 90357-53-2 KSM OF Bicalutamide
21 N-(4-Cyano-3-(trifluromethyl)phenyl)-2-methyloxirane-2-carboxamide 90357-51-0 KSM OF Bicalutamide
22 (3aS,4s,6s,7aR)-2-isobutyl-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]diaoxaborole 84110-34-9 KSM of Bortezomib
23 (3aS,4s,6s,7aR)-2-((S)-1-chloro-3-methylbutyl)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]diaoxaborole 85167-14-2 KSM of Bortezomib
24 (R)-3-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butan-1-amine 179324-86-8 ADI of Bortezomib
25 N-((2S)-1-(((1R)-3-methyl-1-((3aS,4S,6S)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide NA intermediate of Bortezomib API
26 Methyl  L-phenylalaninate.  HCI 7524-50-7 KSM of Bortezomib
27 Methyl (pyrazine-2-carbonyI)- L-phenylalaninate 73058-37-4 KSM of Bortezomib
28 (Pyrazine-2-carbonyl) L-phenylalanine 1093959-75-1 ADI of Bortezomib
29 ((3aR,4R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro [3,4-d] [1,3] dioxol-4-yl)methyl 4-methylbenzenesulfonate 4137-56-8 KSM of Capecitabine
30 (3aR,6R,6aR)-4-methoxy-2,2,6-trimethyl tetrahydrofuro[3,4-d][1, 3]dioxole NA KSM of Capecitabine
31 (2S,3R,4R,5R )-5-methyltetrahydrofuran- 2,3,4-triyl triacetate 62211-93-2 KSM of Capecitabine
32 (2R,3R,4R,5R )-2- (4-amino-5-fluoro-2-oxopyrimidin- 1(2H)-yl)-5-methyltetrahydrofuran-3,4-diyl diacetate 161599-46-8 ADI of Capecitabine
33 Cyclobutane-1,1-dicarboxylic  acid 5445-51-2 KSM of Carboplatin
34 I,3-bis(2-chloroethyl)urea 2214-72-4 KSM of Carmustine
35 tert-butyl 4-((methylsu1fonyl)oxy) piperidine- 1-carboxylate 141699-59-4 KSM of Crizotinib
36 tert-butyl  4-(4-iodo-1H-pyrazol-1-yl)piperidine-1- carboxylate 877399-73-0 KSM of Crizotinib
37 (S)-1-(2,6-dichloro-3-f1uorophenyl)ethan-I-ol 877397-65-4 RM of Crizotinib
38 (R)-3-(1 -(2,6-dichloro-3-fluorophenyl) ethoxy)-2-nitropyridine 877397-70-1 KSM of Crizotinib
39 (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine 877397-71-2 KSM of Crizotinib
40 (R)-5- bromo-3-(1-(2 ,6-dichloro-3- fiuorophenyl)ethoxy)pyridin-2-amine 877399-00-3 KSM of Crizotinib
41 2-Chloro-4- (1H- pyrazol-3-yl)benzonitrile 1297537-37-1 KSM of Darolutamide
42 (S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-ch1orobenzonitri1e 1297537-41-7 KSM of Darolutamide
43 (E)-3-ethoxyacryloyl chloride 6191-99-7 KSM of Dasatinib
44 (E)-N-(2-chloro-6-methylphenyl)-3- ethoxyacrylamide 863127-76-8 KSM of Dasatinib
45 2-amino-N-(2-ch1oro-6-methylphenyl)thiazole-5- carboxamide 302964-24-5 KSM of Dasatinib
46 2-[(6-Chloro-2-methylpyrimidin-4-yl)amino]-N-(2-chloro-6- methylphenyl)thiazole-5-carboxamide 302964-08-5 Intermediate of Dasatinib
47 2-Methylpyrimidine-4,6-diol 40497-30-1 SM of Dasatinib
48 4,6-Dichloro-2-methylpyrimidine 1780-26-3 KSM of Dasatinib
49 2-(piperazin-1-yl)ethan-1-o1 103-76-4 KSM of Dasatinib
50 (2aR,4S,4aS,6R,9S,11S,12S,12aR, 12bS)-12b-acetoxy-9,11-dihydroxy- 4a,8,13,l3-tetramethyl-5-oxo-4,6-bis(((2,2,2-trichloroethoxy)carbonyl)oxy)- 2a,3,4,4a,5,6,9,10,11,12,12a, 12b-dodecahydro- 1H-7,11- methanocyclodeca[3,4]benzo[1,2 -b]oxet- 12-yl benzoate NA KSM of Docetaxel
51 5-((2aR,4S,4aS,6R,9S,11S, 12S,12aR ,12bS)- 12b-acetoxy- 12- (benzoyloxy)-11 -hydroxy-4a,8,13,13- tetramethyl-5- oxo-4,6-bis(((2,2,2 -trichloroethoxy)carbony1)oxy)2a,3,4,4a,5,6,9,l0,11,12,12a, 12b-dodecahydro-1H-7,11- methanocyclodeca[3,4]benzo[1,2-b]oxet-9-yl) 3-(tert-butyl)(4S,5R)-2-(4-methoxyphenyl)-4-phenyloxazolidine-3,5-dicarboxylate NA KSM of Docetaxel
52 Benzenepropanoic acid, b-[[( 1,1-diMethylethoxy) carbonyI]aMino]-a-hydroxy-,(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)- 12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12, l2a,12b-, Docetaxel intermcdiate 114915-14-9 Intermediate of Docetaxel
53
4-Amino-2-(trifluoromethyl)benzonitrile
654-70-6 KSM of Enzalutamide
54 4-Nitro-2-(trifluoromethyl)benzonitrile 320-37-6 KSM of Enzalutamide
55 4-Bromo-3 -(trifluoromethyI)aniline 393-36-2 KSM of Enzalutamide
56 4-((2-cyanopropan-2-yl)amino)- 2-f1uoro-N-methylbenzamide 915087-32-0 Intermediate  of Enzalutamide

ENZALUTAMIDE - API

S.NO NAME OF INTERMEDIATE CAS NO. CATEGORY
57 Ethyl  3,4dihydroxy  benzoate 3843-89-3 SM of Erlotinib HCL
58 Ethyl  3,4-bis(2-methoxyethoxy)benzoate 183322-16-9 Intermediate of Erlotinib HCL
59 Ethyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate 179688-26-7 Intermediate of Erlotinib HCL
60 Ethyl  2-amino-4,5-bis(2-methoxyethoxy)benzoate 179688-27-8 Intermediate of Erlotinib HCL
61 6,7-bis(2-methoxyethoxy)quinazolin-4(3H)-one 179688-29-0 Intermediate of Erlotinib HCL
62 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline 183322-18-1 Intermediate of Erlotinib HCL
63 3-((R)-2,2-diethyI-1,3-dioxoIan-4-yl)- 2,2-difIuoro-3-hydroxypropanoic acid- tertiary butyl amine salt NA Intermediate of Gemcitabine HCL
64 Ethyl 3-((R)-2,2-diethyl-1,3-dioxoIan-4-yl)- 2,2-difluoro-3-hydroxypropanoate 928797-50-6 Intermediate of Gemcitabine HCL
65
(2R,3R)-4,4-difIuoro-5-hydroxytetra hydrofuran-2,3-diyI dibenzoate
143157-22-6 Intermediate of Gemcitabine HCL
66 (2R,3R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-2- ((benzoyloxy)methyI)-4,4-difIuorotetrahydrofuran-3-yl benzoate NA Intermediate of Gemcitabine HCL
67 4-amino-1-((4R,5R)-3,3-difluoro-4-hydroxy- 5-(hydroxymethyl)tetrahydrofuran-2- yl)pyrimidin-2( 1H)-one NA Intermediate of Gemcitabine HCL
68 3-Hydroxy-4-methoxybenzoic acid 645-08-9 SM of Gefitinib
69 Ethyl 3-hydroxy-4-methoxybenzoate 148527-38-2 SM of Gefitinib
70 4-(3-Chloropropyl)morpholine 7357-67-7 KSM of Gefitinib
71 Ethyl 4-methoxy-3-(3-morpholinopropoxy)benzoate 675126-28-0 Intermediate of Gefitinib
72 Ethyl 4-mcthoxy-5-(3-morpholinopropoxy)-2-nitrobenzoate NA Intermediate of Gefitinib
73 Ethyl 2-amino-4-methoxy-5-(3-morpholino propoxy)benzoate NA Intermediate of Gefitinib
74
7-Methoxy-6-(3-morpholinopropoxy) quinazolin-4(3H)-one
199327-61-2 Intermediate of Gefitinib
75 4-(3-((4-Chloro-7-methoxyquinazolin-6-yl)oxy)propyl)morpholine NA Intermediate of Gefitinib
76 3-Chloro-4-fluoroaniline 367-21-5 KSM  of Gefitinib
77 Ethyl (E)-6-(furan-2-yl)-6-oxohex-2-enoate NA SM of Eribulin Fragment- A
78 Ethyl (S,E)-6-(furan-2-yl)-6-hydroxyhex-2-enoate NA Intermediate of Eribulin Fragment- A
79 Ethyl (S,E)-5-(3,6-dioxo-3,6-dihydro-2H-pyran-2-yl)pent-2-enoate NA Intermediate of Eribulin Fragment- A
80 Ethyl (E)-5-((2S,3R)-3-hydroxy-6-oxo-3,6-dîhydro- 2H-pyran-2-yl)pent-2-enoate NA Intermediate of Eribulin Fragment- A
81 Ethyl 2-((2R,4aS,8aR)-6-oxo-2,3,4,4a,6,8a-hexahydropyrano[3,2-b]pyran-2-yl)acetate NA Intermediate of Eribulin Fragment- A
82 Ethyl  2-((2R,4aS,7S,8S,8aS-7,8-bis((tert- butyldimethylsilyl)oxy)-6-oxooctahydropyrano[3,2-b]pyran- 2-yl)acetate NA Intermediate of Eribulin Fragment- A
83 Ethyl 2-((2R,4aS,7S,8S,8aS)-7,8-bis( (tert- butyldimethylsilyl)oxy)-6-methy1eneoctahydropyrano[3,2- b]pyran-2-yl)acetate NA Intermediate of Eribulin Fragment- A
84 Ethyl 2-((2R,4aS,6S,7R,8S,8aS-7,8-bis((tert- butyldimethylsilyl)oxy)-6- (hydroxymethyl)octahydropyrano[3,2- b]pyran-2- yl)acetate NA Intermediate of Eribulin Fragment- A
85 Ethyl  2-((2R,4aS,6S,7R,8S,8aS-7,8-Bis((tert- butyldimethylsilyl)oxy)-6-(2-oxoethyl)octahydropyrano[3,2-b]pyran-2-yl)acetate NA Intermediate of Eribulin Fragment- A
86 Ethyl 2-((2R,4aS,7R,8S,8aS)-7,8-bis((tert-butyldimethylsilyl)oxy)-6-((S)-1 -hydroxy-3- (trimethylsilyl)prop-2-yn-1-yl)octahydropyrano[3,2-b]pyran-2-yl)acetate NA Intermediate of Eribulin Fragment- A
87 methyl  2-((2R,4aS,7R,8S,8aS)-7,8-bis((tert butyldimethylsilyl )oxy)-6-((S,E)-1-((tert-butyldimethylsilyl)oxy)-3- iodoallyl)octahydropyrano[3,2-b]pyran-2-y1)acetate 157322-83-3 Intermediate of Eribulin Fragment- A
88 2-((2R,4aS,7R,8S,8aS)-7,8-bis((tert-butyldimethylsi1yl)oxy)-6- (S,E)-1-hydroxy-3-iodoallyl)octahydropyrano[3,2-b]pyran-2- yl)acetaldehyde NA Intermediate of Eribulin Fragment- A
89 2-(hydroxy(4-phenoxyphenyl)methylene)malononitrile 330792-68-2 Intermediate of KSM
90 2-(methoxy(4-phenoxyphenyl)methylene)malononitrile 330792-69-3 Intermediate of KSM
91 5-amino-3-(4-phenoxybenzyl)-1H-pyrazole-4-carbonitrile 330792-70-6 Intermediate of KSM
92   3-(4-phenoxyphenyl)-1 H-pyrazolo[3,4-d]pyrimidin-4-amine 330786-24-8 KSM of Ibrutinib
93 (S)-3-(4-phenoxyphenyl)-1-(piperidine-3yl)-1H-pyrazolo[3,4,d]pyrimidine-4-amine 1022150-12-4 Intermediate of Ibrutinib API
94 4-((4-methylpiperazin-1 -yl)methyl)benzoic acid 106261-48-7 KSM of Imatinib
(E)-3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1 -one 66521-54-8 KSM of Imatinib
96 N-(2-methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2- amine 152460-09-8 Intermediate of Imatinib
97 6-methyl-N1-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine 1032314-73-0 Intermediate of Imatinib
98 4-((4-methyl piperazin-1-yl)methyl)benzonitrile 125743-63-7 KSM of Imatinib
99 1-(2-methyl-5-nitrophenyl)guanidine NA KSM of Imatinib
100 4-methylbenzonitrile 104-85-8 SM of Imatinib

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